The genetics of inbreeding depression pdf

Charlesworth, D. Inbreeding depression and its evolutionary consequences. Annual Review of Ecology and Systematics — DOI: Review of how the genetic load of mostly recessive deleterious mutations manifests as inbreeding depression and how these effects modify load dynamics and the evolution of other e.

Reviews support for the role of dominance rather than overdominance as the genetic basis for inbreeding effects. Charlesworth, B. The genetic basis of inbreeding depression. Genetical Research — A clear review of the theory and empirical evidence for directional dominance as the primary mechanism causing inbreeding depression. They also describe the meager data available on the distribution of mutational effects and implications of these for how inbreeding depression evolves.

The genetics of inbreeding depression. Nature Reviews Genetics — A general review of the basis for inbreeding depression, drawing on both theory and recent empirical evidence. The article stresses the practical significance of inbreeding depression for understanding the dynamics of mating system evolution and methods and outcomes in plant and animal breeding. Crow, J. Mutation, mean fitness, and genetic load. Oxford Series in Evolutionary Biology — Authoritative historical review of the ideas and theory related to genetic load, including how recurrent mutations with various effect sizes and levels of dominance affect population fitness.

Emphasizes how the architecture of the genetic load varies depending on population size and discusses evidence that dominance rather than overdominance tends to generate most of the inbreeding depression we observe. Hedrick, P. The hybrid breakdown part of inbreeding depression values of individual RILs were negatively associated with the heterosis measurements of their BC or testcross hybrids, indicating the partial genetic overlap of genes causing hybrid breakdown and heterosis in rice.

Two conclusions concerning the loci associated with inbreeding depression and heterosis in rice were reached from our results. First, most QTL associated with inbreeding depression and heterosis in rice appeared to be involved in epistasis. These observations tend to implicate epistasis and overdominance, rather than dominance, as the major genetic basis of heterosis in rice.

The implications of our results in rice evolution and improvement are discussed. These references are in PubMed. This may not be the complete list of references from this article. National Center for Biotechnology Information , U. Journal List Genetics v. Zhang, C. The genetic basis of inbreeding depression in potato. Nat Genet 51, — Download citation. Received : 20 June Accepted : 21 November Published : 14 January Issue Date : March Anyone you share the following link with will be able to read this content:.

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Subjects Plant breeding Plant genetics. Abstract Inbreeding depression confers reduced fitness among the offspring of genetic relatives. Access through your institution. Buy or subscribe. This is a preview of subscription content.

Change institution. Buy article Get time limited or full article access on ReadCube. Code availability The pipeline of parent-independent genotyping in potato was written using custom Python scripts.

References 1. Book Google Scholar 2. Article Google Scholar 5. CAS Google Scholar 6. Article Google Scholar Google Scholar Acknowledgements We thank J. Tawari Authors Chunzhi Zhang View author publications. View author publications. Ethics declarations Competing interests The authors declare no competing interests. Integrated supplementary information. Supplementary Figure 1 S-RNase expression in flowers at the bud stage.

Supplementary Figure 2 Deleterious substitutions are enriched in low-recombination regions. Supplementary Figure 3 Pipeline for parent-independent genotyping-by-sequencing in potato. Supplementary Figure 4 Bin maps of three selfing populations. Supplementary Figure 6 Genetic mapping of the large-effect deleterious alleles affecting survival and growth vigor. Supplementary Figure 8 Genetic mapping of pollen viability and yield. Reporting Summary.

Rights and permissions Reprints and Permissions. About this article. Suitability of different mapping algorithms for genome-wide polymorphism scans with pool-seq data. G3 Bethesda 6 11 : — Bioinformatics 27 24 : — Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression. Lande R , Schemske DW. The evolution of self-fertilization and inbreeding depression in plants. Evolution 39 1 : 24 — Latter BDH.

Mutant alleles of small effect are primarily responsible for the loss of fitness with slow inbreeding in Drosophila melanogaster. Balancing selection maintains hyper-divergent haplotypes in Caenorhabditis elegans.

Nat Ecol Evol. Toward better understanding of artifacts in variant calling from high-coverage samples. Bioinformatics 30 20 : — Li H , Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25 14 : — Dissecting repulsion linkage in the dwarfing gene Dw3 region for sorghum plant height provides insights into heterosis. Population-genetic inference from pooled-sequencing data. Genome Biol Evol. Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium.

Mol Microbiol. The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genetic properties of the maize nested association mapping population. Science : — Nagylaki T.

Introduction to theoretical population genetics. New York NY : Springer. Nigon V , Dougherty EC. Reproductive patterns and attempts at reciprocal crossing of Rhabditis elegans Maupas, , and Rhabditis briggsae Dougherty and Nigon, Nematoda: Rhabditidae. J Exp Zool.

Selfing is the safest sex for Caenorhabditis tropicalis. Elife 10 : e Otte KA , Schlotterer C. Detecting selected haplotype blocks in evolve and resequence experiments.

Mol Ecol Resour. Natural and experimental evolution of sexual conflict within Caenorhabditis nematodes. BMC Evol Biol. Phillips PC. Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26 6 : — Genetic rescue: a critique of the evidence supports maximizing genetic diversity rather than minimizing the introduction of putatively harmful genetic variation. Biol Conservat.

Purging of strongly deleterious mutations explains long-term persistence and absence of inbreeding depression in island foxes. Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. Sci Adv. Rockman MV , Kruglyak L. Recombinational landscape and population genomics of Caenorhabditis elegans. The genome-wide dynamics of purging during selfing in maize. Nat Plants. Individual heterozygosity predicts translocation success in threatened desert tortoises.

Widespread genetic incompatibility in C. Genetic architecture of nonadditive inheritance in Arabidopsis thaliana hybrids.

Genetic load may increase or decrease with selfing depending upon the recombination environment. Smith JM. The evolution of sex. Strikingly high levels of heterozygosity despite 20 years of inbreeding in a clonal honey bee.

J Evol Biol. The power of evolutionary rescue is constrained by genetic load. Sudhaus W , Kiontke K. Phylogeny of Rhabditis subgenus Caenorhabditis Rhabditidae, Nematoda. J Zool Syst Evol Res. Quantifying selection with pool-seq time series data. Chromosome-level assembly of the Caenorhabditis remanei genome reveals conserved patterns of nematode genome organization. Genetics 4 : — Waller DM.

Evolution 75 4 : — The panda and the phage: compensatory mutations and the persistence of small populations. Identifying consistent allele frequency differences in studies of stratified populations. Methods Ecol Evol. Wright S. The distribution of gene frequencies under irreversible mutation.

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Department of Biological Sciences, University of Alabama. Oxford Academic. Anna B Crist. Department of Genomes and Genetics, Institut Pasteur. Ellen M Young. Institute of Ecology and Evolution, University of Oregon. John H Willis. Patrick C Phillips. Janna L Fierst. Corresponding author: E-mail: jfierst fiu. Select Format Select format. Permissions Icon Permissions.

Abstract The deleterious effects of inbreeding have been of extreme importance to evolutionary biology, but it has been difficult to characterize the complex interactions between genetic constraints and selection that lead to fitness loss and recovery after inbreeding. Open in new tab Download slide. Table 1. Paired t- Test Results for Average Fecundity. Group 1. Group 2. P -value. Ancestor Inbred 1. Open in new tab. Table 2. GLM Results. Gene, Ortholog, and Protein Information. InterProScan and snpEff Annotations.

Contig: position 0: ; 2. Synonymous Variant 0: ; ; 2. Intron Variants 1: 1. Intron Variant 3: 2.